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Cord Blood Information



What is cord blood?


Cord blood is the blood remaining in the umbilical cord and placenta following delivery. The child' s umbilical cord and placenta are typically discarded post-partum; however, more recently, it has been recognized that blood from the umbilical cord is rich in potentially life-saving stem cells. Stem cells are early-stage cells with the potential to self-renew and to regenerate new cells and tissues. Due to this regenerative capability, stem cells play a vital role in the treatment of leukemia and other cancers. To date, nearly 50 different types of blood cancers and disorders have been treated with cord blood.

Applications of Cord Blood Stem Cells


Cancers


Acute Lymphocytic Leukemia (ALL)

Acute Myelogenous Leukemia (AML)

Chronic Myelogenous Leukemia (CML)  

Chronic Myelomonocytic Leukemia (CMML)

Hodgkins Disease

Juvenile Chronic Myelogenous Leukemia (JCML)

Juvenile Myelomonocytic Leukemia (JMML)

Neuroblastoma

Non-hodgkins Lymphoma

Refractory Anemia (RA)

Refractory Anemia with Excess Blasts (RAEB)

Bone Marrow Failure


Aplastic Anemia  (Severe)

Amegakaryocytic Thrombocytopenia

Diamond-Blackfan Anemia

Dyskeratosis Congenita

Fanconi Anemia 

Kostmann Syndrome


Immune System Disorders


Omenn Syndrome

Severe Combined Immunodeficiency (SCID)

Wiskott-Aldrich Syndrome

X-Linked Lymphoproliferative Disorder Immune System Disorders


Blood Disorders


Beta Thalassemia Major

Sickle Cell Disease


Inborn Errors of Metabolism


Adrenoleukodystrophy

Erythrophagocytic Lymphohistiocytosis

Gunther Disease

Histiocytic Disorders

Hunter Syndrome (MPS-II)

Hurler Syndrome (MPS-IH)

Krabbe Disease

Lesch-Nyhan Syndrome

Osteopetrosis


Autoimmune Diseases


Multiple Sclerosis

Rheumatoid Arthritis

Systemic Lupus Erythematosus


What are stem cells?


Upon fertilization, the egg and sperm form a 'zygote', from which all other cells in the body are derived for the rest of the person' s lifetime.  As the zygote continues to divide, the resulting embryo consists of cells with the special ability to generate all the organs and tissues in the human body.  These special cells are called 'stem cells', as they are literally, the stem from which all other cell types arise.

Why are stem cells medically important?


As cells continue to divide and grow, many of them become "differentiated", meaning that they can no longer further give rise to more cells.  Examples of such terminally differentiated cells include brain cells and heart cells.  It is because brain and heart cells are differentiated that damage to such cells are life threatening, as in the case of heart attacks, stroke, and spinal cord injuries.  There are many more diseases caused by irreparable injuries, including diabetes, arthritisAlzheimer's Disease, and Parkinson's Disease to name just a few.

Current medicine provides largely symptomatic treatment of such diseases.  However, the next generation of medical therapies will arise from stem cell research that is currently being conducted at a rapid pace around the world.

The first cord blood transplant was performed in 1988 in France for a child with Fanconi Anemia  (a rare, lethal blood disorder).  The patient is alive and well today.  During the past twenty years, cord blood banking has developed into a scientifically and medically accepted means of storing stem cells, and has been used in the treatment of over 50 diseases, including cancers and various blood disorders.

While thousands of cord blood transplants have been performed to date, many parents are still not fully aware of the importance of cord blood banking, whether for public donation, or for private banking for family use.

Cord Blood Stem Cell Research


At the moment, stem cells are used in the treatment of over 50 cancers, immune disorders, and genetic disorders. As technology progresses, it is likely that the field of stem cells therapy will become more advanced, and the future uses of stem cells can be limitless. Research in stem cell therapy include usage for treatment of heart diseases, spinal cord injury, stroke, diabetes, and muscular dystrophy


Applications of Cord Blood Stem Cell


Disease Treatments


Parkinson's Disease

Cord Blood Association of Canada Endeavor to Cord Blood Education. Alzheimer's Disease

Spinal Cord Injury

Huntington's Disease

Amyotrophic Lateral Sclerosis (ALS)

Stroke

Muscular Dystrophy

Diabetes

Heart Disease

Liver Disease


Regenerative Medicine


Cellular Cardiomyoplasty

Vascular Regeneration

Skin Growth

Liver Repair

Kidney Repair

 

Ex-Vivo Stem Cell Expansion

 

Gene Therapy

 


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